Chemical Influence of Scutellaria baicalensis—Coptis chinensis Pair on the Extraction Efficiencies of Flavonoids and Alkaloids at Different Extraction Times and Temperatures

The Scutellaria baicalensis—Coptis chinensis pair is an herbal combination used for the treatment of various heat-related diseases. During extraction process, two herbs can mutually influence efficiency chemical constituents contained in each herb. concentrations five flavonoids from S. baicalensis and seven alkaloids C. were compared paired or single hot-water extracts at different temperatures (80, 90, 100 °C) times (60, 120 min). Temperature- time-dependent increases marker compound observed both extracts, with exception baicalin, berberine, coptisine °C. However, extractions compounds affected differently by conditions. Furthermore, most 1.09–44.13 those extracts. contents wogonoside, coptisine, known to be easily aggregated flavonoid–alkaloid complex, changed 0.024–0.764-fold extract. effect temperature time on formation complex was not significant. baicalensis—C. chinensis, which a primary factor modification herb-containing